Pathogenesis of hypoxic-ischemic brain injury
نویسندگان
چکیده
منابع مشابه
Hypoxic-Ischemic Brain Injury in Piglets
Background and Purpose: The excitatory amino acid inhibitor MK-801 has been shown in many animals species to protect against hypoxic-ischemic brain injury. We sought to determine whether hypoxic-ischemic injury to the newborn pig's brain could be prevented by the use of MK-801. Methods: Hypoxic-ischemic injury to the brain was induced in forty 0-3-day-old piglets. They were randomized to receiv...
متن کاملPathogenesis of hypoxic-ischemic brain injury in a perinatal rodent model.
Exposure of immature rats to 8% oxygen after unilateral carotid artery ligation (UCL) causes metabolic, neurochemical and histopathological changes in the ipsilateral forebrain that resemble those in human perinatal hypoxic-ischemic encephalopathy. Regional cerebral perfusion in this model was examined by visual analysis of India ink trapped in cerebral vessels and measurement of [14C]iodoantip...
متن کاملExcitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury.
A large body of experimental evidence indicates that over-activation of excitatory amino acid (EAA) receptors may mediate irreversible neuronal injury in a variety of pathologic settings including cerebral ischemia, and that the developing brain may be particularly susceptible to the adverse effects of EAA receptor overactivation. In this article, we review current information about EAA recepto...
متن کاملA rat model of severe neonatal hypoxic-ischemic brain injury.
BACKGROUND AND PURPOSE Perinatal hypoxic-ischemic brain injury is a common problem with severe neurological sequelae. In this report we describe in detail a simple model of hypoxia-ischemia in the neonatal rat that gives rise to severe neocortical infarction and to selective hippocampal neuronal necrosis. METHODS Seven-day-old Simonsen Wistar rat pups underwent bilateral carotid artery ligati...
متن کاملRole of Mitochondria in Neonatal Hypoxic-Ischemic Brain Injury
Hypoxic-ischemia (HI) causes severe brain injury in neonates. It's one of the leading causes to neonatal death and pediatric disability, resulting in devastating consequences, emotionally and economically, to their families. A series of events happens in this process, e.g. excitatory transmitter release, extracelluar Ca2+ influxing, mitochondrial dysfunction, energy failure, and neuron death. T...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2007
ISSN: 0743-8346,1476-5543
DOI: 10.1038/sj.jp.7211716